Structural Genomics and Structure-based Drug Design
نویسندگان
چکیده
منابع مشابه
CABM Symposium Applications of NMR to structure-based drug design in structural genomics
Structural genomics is poised to have a tremendous impact on traditional structure-based drug design programs. As a result, there is a growing need to obtain rapid structural information in a reliable form that is amenable to rational drug design. In this manner, NMR has been expanding and evolving its role in aiding the design process. A variety of NMR methodologies that cover a range of inher...
متن کاملStructural genomics and drug discovery
Structure determination has already proven useful for lead optimization and direct drug design. The number of high-resolution structures available in public databases today exceeds 30,000 and will definitely aid in structure-based drug design. Structural genomics approaches covering whole genomes, topologically similar proteins or gene families are great assets for further progress in the devel...
متن کاملStructural Genomics Support for Infectious Disease Drug Design
Robin Stacy,†,‡ Wayne F. Anderson, and Peter J. Myler*,†,‡,⊥ †Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, Washington 98109, United States ‡Seattle Structural Genomics Center for Infectious Disease, 307 Westlake Ave North, Suite 500, Seattle, Washington 98109, United States Department of Molecular Pharmacology and Biological Chemistry, Northwestern Unive...
متن کامل[Structure-based drug design].
Structure-based drug design is not only a fundamental tool in the search of new drugs but also an area of intensive scientific research. The present contribution starts with a critical analysis of the potentiality of the structure based design and then reviews its methods. Protein crystallography, NMR, homology modelling and the use of antibodies are either referenced or briefly described as th...
متن کاملStructure-Based Drug Design
Volume 1 • Issue 4 • 1000e111 J Pharmacovigilance ISSN: 2329-6887 JP, an open access journal In today’s world where life is fast-paced, public health is a big concern. With the tremendous ongoing development in the field of pharmaceutical drugs, people can find cure for a vast variety of diseases. These modern-day medicines have been proven to be more effective in treating, managing, controllin...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2000
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.116.supplement_23